1Amazon Woman™ — (tonic) — Libido Formula - Female Libido Enhancer
Formulated for a woman’s chemistry, Amazon Woman™ is a proprietary blend
of botanicals used to stimulate sexual appetite and desire, increase
sexual behavior and address several female concerns. [1,2,3,4,5,6,7,8,9,11] Ingredients in this
formula are well known aphrodisiacs that nourish glandular function,
increase libido, and balance the mind and body. [1,2,3,4,5,6,7,8]. It decreases anxiety, lowers inhibitions, and increases circulation and
lubrication in the genitals. [5,6,7,8,9,10,11,12,13] Many females have reported that it works very quickly!!
Suggested Use: Liquids:
Use 10-15 drops mixed with water two to three times daily or as
recommended by a practitioner.
Cautions: Contains Damiana which may reduce
the absorption of iron. Contains raspberry which should not be used in
the early stages of pregnancy. Use under care/advice of a medical
practitioner. Not intended for long term therapy.
Contraindications: Do not use if anemic.
Pregnant women should consult with their physician before taking this
product.
Ingredients: Maca
(Lepidium peruvianum), Clavo Huasca (Tynanthus panurensis), Damiana (Turnera diffusa), Milky Oats
(Avena sativa), Rosemary (Rosmarianus
officinale), Raspberry Leaf (Rubus ideaus),
vegetable glycerine, distilled water and organic grain alcohol. ------------------------------------------------------------------------------------------
More About Amazon Woman™
Maca Lepidium puruvianum: Contributes to overall well being with its nourishing effect on the
nervous system.
Clavo Huasca Tynanthus
panurensis: Well known as an aphrodisiac for men and women. Has a mischevious
reputation for often having been employed in women’s love potions.
Damiana Turnera diffusa: Damiana leaves are said to have atidepressant and aphrodisiac properties.
Milky Oats Avena sativa: Has been used to assist the body in modulating glucose and insulin
levels Relaxes the central nervous system.
Rosemary Rosmarianus officinale: Has been used for its antibacterial, antifungal effects.
Raspberry Leaf Rubus ideaus: Has been as a relaxant and to tone the uterus. Has been used to relieve
anxiety and inflammations.
Maca Lepidium puruvianum
1. Smallanthus sonchifolius and Lepidium meyenii -
prospective Andean crops for the prevention of chronic diseases.
Valentova K, Ulrichova J.
Institute of Medical Chemistry and Biochemistry, Faculty of Medicine,
Palacky University, Hnevotinska 3, Olomouc, 775 15, Czech Republic.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2003
Dec;147(2):119-30.
2. Effects of Lepidium meyenii Walp and Jatropha
macrantha on blood levels of estradiol-17 beta, progesterone,
testosterone and the rate of embryo implantation in mice.
Oshima M, Gu Y, Tsukada S.
Graduate School of Medical Imaging, Suzuka University of Medical
Science, Suzuka-shi, Mie, Japan.
J Vet Med Sci. 2003 Oct;65(10):1145-6.
PMID: 14600359 [PubMed - indexed for MEDLINE]
3. Lepidium peruvianum chacon restores homeostasis
impaired by restraint stress.
Lopez-Fando A, Gomez-Serranillos MP, Iglesias I, Lock O, Upamayta UP,
Carretero ME.
Dpto Farmacologia, Facultad de Farmacia, Universidad Complutense,
Madrid, Spain. Phytother Res. 2004 Jun;18(6):471-4
PMID: 15287072 [PubMed - indexed for MEDLINE]
4. Acute and chronic dosing of Lepidium meyenii
(Maca) on male rat sexual behavior.
Lentz A, Gravitt K, Carson CC, Marson L.
Division of Urology, Department of Surgery, University of North
Carolina, Chapel Hill, NC, USA. J Sex Med. 2007
Mar;4(2):332-9; discussion 339-40.
PMID: 17367428 [PubMed - in process] Clavo Huasca ‘Tynanthus
panurensis’
5.“...pieces of roots and stems are macerated in aguardiente to make a
stimulant liqueur, good for rheumatism (RVM). Resin used for fevers
(DAT). Some explorama visitors have used it, effectively, for toothache,
being as effective as, and probably chemically similar to clove oil
(JAD). Some visitors believe, others disbelieve, that the rays of the
cross, steeped in aguardiente, are aphrodisiac, some for females, some
for males, some for both. We have no incontrovertible empirical
evidence, one way or the other.”
— Duke, James A and Vasquez, Rodolfo, Amazonian Ethnobotanical
Dictionary. CRC Press, Inc., 1994. Damiana ‘Turnera diffusa’
6. Stimulating property of Turnera diffusa and
Pfaffia paniculata extracts on the sexual-behavior of male rats.
Arletti R, Benelli A, Cavazzuti E, Scarpetta G, Bertolini A.
Department of Biomedical Sciences, Section of Pharmacology, University
of Modena and Reggio Emilia, Italy. farmacol@unimo.it
Psychopharmacology (Berl). 1999 Mar;143(1):15-9.
PMID: 10227074 [PubMed - indexed for MEDLINE]
7. Anti-anxiety Activity Studies on Homoeopathic
Formulations of Turnera aphrodisiaca Ward.
Kumar S, Sharma A.
Evid Based Complement Alternat Med. 2005 Mar;2(1):117-119. Epub 2005 Feb
9.
PMID: 15864356 [PubMed - as supplied by publisher]
8. Analysis of essential oils from wild and
micropropagated plants of damiana (Turnera diffusa).
Alcaraz-Melendez L, Delgado-Rodriguez J, Real-Cosio S.
Programa de Agricultura de Zonas Aridas, Centro de Investigaciones
Biologicas del Noroeste, P.O. Box 128, La Paz,Baja California Sur 23000,
Mexico. lalcaraz04@cibnor.mx
Fitoterapia. 2004 Dec;75(7-8):696-701.
PMID: 15567246 [PubMed - indexed for MEDLINE]
9. Argentinian plant extracts with relaxant effect on
the smooth muscle of the corpus cavernosum of guinea pig.
Hnatyszyn O, Moscatelli V, Garcia J, Rondina R, Costa M,
Arranz C, Balaszczuk A, Ferraro G, Coussio JD.
Catedra de Farmacognosia, IQUIMEFA (UBA-CONICET), Facultad de Farmacia y
Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina.
ohnatys@ffyb.uba.ar
PMID: 14692728 [PubMed - indexed for MEDLINE] Milky Oats ‘Avena sativa’
10. Diets containing soluble oat extracts improve
glucose and insulin responses of moderately hypercholesterolemic men and
women.
Hallfrisch J, Scholfield DJ, Behall KM.
US Department of Agriculture, Beltsville Human Nutrition Research
Center, MD 20705.
Am J Clin Nutr. 1995 Feb;61(2):379-84. Rosemary ‘Rosmarinus officinalis’
11. Antiplatelet activity of carnosic acid, a
phenolic diterpene from Rosmarinus officinalis.
Lee JJ, Jin YR, Lee JH, Yu JY, Han XH, Oh KW, Hong JT, Kim TJ, Yun YP.
College of Pharmacy, Research Center for Bioresource and Health,
Chungbuk National University, Cheongju, Korea. Planta Med. 2007
Feb;73(2):121-7.
PMID: 17410649 [PubMed - in process] Raspberry Leaf ‘Rubus ideaus’
12. Therapeutic constituents and actions of Rubus
species.
Patel AV, Rojas-Vera J, Dacke CG.
School of Pharmacy and Biomedical Sciences, University of Portsmouth,
Portsmouth, PO1 2DT, UK. asmita.sautreau@port.ac.uk
Curr Med Chem. 2004 Jun;11(11):1501-12.
Publication Types: Review, Review, Tutorial
PMID: 15180580 [PubMed - indexed for MEDLINE]
13. Relaxant activity of raspberry (Rubus idaeus)
leaf extract in guinea-pig ileum in vitro.
Rojas-Vera J, Patel AV, Dacke CG.
School of Pharmacy and Biomedical Sciences, University of Portsmouth,
Portsmouth, PO1 2DT, UK.
Phytother Res. 2002 Nov;16(7):665-8.
PMID: 12410549 [PubMed - indexed for MEDLINE]
Maca Lepidium puruvianum
1. Smallanthus sonchifolius and Lepidium meyenii -
prospective Andean crops for the prevention of chronic diseases.
Valentova K, Ulrichova J.
Institute of Medical Chemistry and Biochemistry, Faculty of Medicine,
Palacky University, Hnevotinska 3, Olomouc, 775 15, Czech Republic.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2003
Dec;147(2):119-30. Smallanthus sonchifolius (yacon) and Lepidium meyenii (maca) were the
traditional crops of the original population of Peru where they are also
still used in folk medicine. These plants are little known in Europe
and Northern America although at least yacon can be cultivated in the
climatic conditions of these regions. This article deals with the botany
and the composition, the structure of main constituents, biological
activity of these plants and the cultivation of yacon in the Czech
Republic. The potential of yacon tubers to treat hyperglycemia, kidney
problems and for skin rejuvenation and the antihyperglycemic and
cytoprotective activity of its leaves seems to be related mostly to its
oligofructan and phenolic content, respectively. Maca alkaloids,
steroids, glucosinolates, isothicyanates and macamides are probably
responsible for its aptitude to act as a fertility enhancer,
aphrodisiac, adaptogen, immunostimulant, anabolic and to influence
hormonal balance. Yacon and maca are already on the European market as
prospective functional foods and dietary supplements, mainly for use in
certain risk groups of the population, e.g. seniors, diabetics,
postmenopausal women etc. 2. Effects of Lepidium meyenii Walp and Jatropha
macrantha on blood levels of estradiol-17 beta, progesterone,
testosterone and the rate of embryo implantation in mice.
Oshima M, Gu Y, Tsukada S.
Graduate School of Medical Imaging, Suzuka University of Medical
Science, Suzuka-shi, Mie, Japan.
J Vet Med Sci. 2003 Oct;65(10):1145-6.
The effects of two Peruvian folk medicines, Lepidium meyenii Walp and
Jatropha macrantha, on mouse sex steroid hormones and embryo
implantation were investigated. Progesterone levels increased
significantly in mice that received L. meyenii Walp, while testosterone
levels increased significantly in mice that received L. meyenii Walp as
well as in those that received both L. meyenii Walp and J. macrantha.
However, there were no marked changes in blood levels of
estradiol-17beta or the rate of embryo implantation.
PMID: 14600359 [PubMed - indexed for MEDLINE]
3. Lepidium peruvianum chacon restores homeostasis
impaired by restraint stress.
Lopez-Fando A, Gomez-Serranillos MP, Iglesias I, Lock O, Upamayta UP,
Carretero ME.
Dpto Farmacologia, Facultad de Farmacia, Universidad Complutense,
Madrid, Spain. Phytother Res. 2004 Jun;18(6):471-4
Lepidium peruvianum root has been traditionally utilized by native
Peruvians, since before the time of the Incas, for both nutritional and
putative medicinal purposes as an adaptogen and also to enhance
fertility in humans and animals. The present research was conducted to
evaluate the anti-stress activity of the methanolic extract of Lepidium
peruvianum. The drug is capable of attenuating or even eliminating
variations in homeostasis produced by stress since it reduces or
abolishes stress-induced ulcers, elevated corticosterone levels, the
reduction of glucose and the increase in the weight of adrenal glands
produced by stress. It also eliminates the decrease in free fatty-acids
(FFA) in plasma produced by stress and we obtain a positive result in
the forced-swimming test. Thus, it did not appear to affect restraint
stress-induced immunosuppression.
PMID: 15287072 [PubMed - indexed for MEDLINE]
4. Acute and chronic dosing of Lepidium meyenii
(Maca) on male rat sexual behavior.
Lentz A, Gravitt K, Carson CC, Marson L.
Division of Urology, Department of Surgery, University of North
Carolina, Chapel Hill, NC, USA. J Sex Med. 2007 Mar;4(2):332-9;
discussion 339-40.
INTRODUCTION: The use of natural remedies for the treatment of sexual
disorders is under current investigation. For generations people of the
rural community in Peru have used Lepidium meyenii Walpers (Maca),
because of their belief that it improves fertility and sexual desire.
AIM: To determine the acute and chronic effects of Maca on male sexual
behavior and to examine chronic administration of Maca on anxiety. MAIN
OUTCOME MEASURES: Ejaculatory and mounting behavior and postejaculatory
interval. Anxiety tests using an elevated plus maze, locomotion, and
social interaction with another male. METHODS: Maca (25 and 100 mg/kg)
was orally administered to male rats for 30 days. Male sexual behavior
was monitored after acute, 7 and 21 days of treatment. Anxiety behavior
and locomotion were measured at 28-29 days using the elevated plus maze
and social interaction tests. RESULTS: Maca treatment did not produce
large changes in male sexual behavior. However, an increase in
ejaculation latency and postejaculatory interval was observed after both
acute and 7 days of treatment. After 21 days of treatment Maca had no
effect on sexual behavior. Chronic administration of Maca did not
increase locomotion or anxiety. CONCLUSION: Acute and short-term
administration of Maca produced a small effect of rat male sexual
behavior and long-term administration did not increase anxiety.
PMID: 17367428 [PubMed - in process]
Clavo Huasca ‘Tynanthus
panurensis’
5. “...pieces of roots and stems are
macerated in aguardiente to make a stimulant liqueur, good for
rheumatism (RVM). Resin used for fevers (DAT). Some explorama visitors
have used it, effectively, for toothache, being as effective as, and
probably chemically similar to clove oil (JAD). Some visitors believe,
others disbelieve, that the rays of the cross, steeped in aguardiente,
are aphrodisiac, some for females, some for males, some for both. We
have no incontrovertible empirical evidence, one way or the other.”
— Duke, James A and Vasquez, Rodolfo, Amazonian Ethnobotanical
Dictionary. CRC Press, Inc., 1994.
Damiana ‘Turnera diffusa’
6. Stimulating property of Turnera diffusa and
Pfaffia paniculata extracts on the sexual-behavior of male rats.
Arletti R, Benelli A, Cavazzuti E, Scarpetta G, Bertolini A.
Department of Biomedical Sciences, Section of Pharmacology, University
of Modena and Reggio Emilia, Italy. farmacol@unimo.it
Psychopharmacology (Berl). 1999 Mar;143(1):15-9.
Sexually potent and sexually sluggish/impotent male rats were treated
orally with different amounts of Turnera diffusa and Pfaffia paniculata
fluid extracts (0.25, 0.50, 1.0 ml/kg). While having no effect on the
copulatory behavior of sexually potent rats, both plant extracts--singly
or in combination--improved the copulatory performance of sexually
sluggish/impotent rats. The highest dose of either extract (1 ml/kg) (as
well as the combination of 0.5 ml/kg of each extract) increased the
percentage of rats achieving ejaculation and significantly reduced
mount, intromission and ejaculation latencies, post-ejaculatory interval
and intercopulatory interval. Neither extract affected locomotor
activity. These results seem to support the folk reputation of Turnera
diffusa and Pfaffia paniculata as sexual stimulants.
PMID: 10227074 [PubMed - indexed for MEDLINE]
7. Anti-anxiety Activity Studies on Homoeopathic
Formulations of Turnera aphrodisiaca Ward.
Kumar S, Sharma A.
Evid Based Complement Alternat Med. 2005 Mar;2(1):117-119. Epub 2005
Feb 9.
Turnera aphrodisiaca Ward (Turneraceae) has been traditionally used
for the treatment of anxiety neurosis, and as an aphrodisiac. Mother
tinctures (85% ethanol extracts) of T. aphrodisiaca have also been used
for the treatment of central nervous system disorders. In the present
investigation, T. aphrodisiaca mother tinctures formulated by three
reputed manufacturers of homoeopathic medicines (NLK, DWSG and SBL) were
evaluated for their anxiolytic activity. Dried mother tinctures of T.
aphrodisiaca were subjected to anxiolytic activity evaluation at various
doses, i.e. 50, 75, 100, 125 or 150 mg/kg p.o. in mice using elevated
plus maze apparatus. Dried mother tinctures exhibited significant
anxiolytic activity at 50 mg/kg (NLK), 75 mg/kg (DWSG) and 125 mg/kg
(SBL), respectively, with reference to control as well as standard
(diazepam, 2 mg/kg p.o.). Mother tinctures of T. aphrodisiaca available
in the market, have significant anxiolytic activity. Amongst the three
mother tinctures of T. aphrodisiaca analyzed, the dry residue of NLK
possesses the highest amount of anxiolytic constituent(s). To ensure
uniformity and consistency of biological effects in herbal formulations,
these should be standardized on the basis of bioactive markers. The
authors are actively involved in isolating the bioactive constituent(s)
from T. aphrodisiaca so that the plant can be standardized on the basis
of biologically active constituent(s).
8. Analysis of essential oils from wild and
micropropagated plants of damiana (Turnera diffusa).
Alcaraz-Melendez L, Delgado-Rodriguez J, Real-Cosio S.
Programa de Agricultura de Zonas Aridas, Centro de Investigaciones
Biologicas del Noroeste, P.O. Box 128, La Paz,
Baja California Sur 23000, Mexico. lalcaraz04@cibnor.mx
Fitoterapia. 2004 Dec;75(7-8):696-701.
Damiana is a medicinal plant with many traditional uses and a
reputation as an aphrodisiac. Essential oils produced by this plant are
used in traditional medicine, and for the preparation of liquors and
tea. The composition of essential oils from wild damiana, plants grown
with micropropagated methods involving cell suspension, and explants in
solid medium, is presented. Relevant differences are observed in oils
coming from wild and micropropagated plants, where micropropagated
plants being more uniform with respect to quality and quantity. The most
abundant constituents of the oils were caryophyllene oxide,
caryophyllene, delta-cadinene, elemene and 1,8-cineol.
PMID: 15567246 [PubMed - indexed for MEDLINE]
9. Argentinian plant extracts with relaxant effect on
the smooth muscle of the corpus cavernosum of guinea pig.
Hnatyszyn O, Moscatelli V, Garcia J, Rondina R, Costa M, Arranz C,
Balaszczuk A, Ferraro G, Coussio JD.
Catedra de Farmacognosia, IQUIMEFA (UBA-CONICET), Facultad de Farmacia
y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina.
ohnatys@ffyb.uba.ar
Extracts of different polarity from Baccharis trimera, Haplopappus
rigidus Huperzia saururus, Maytenus ilicifolia, Satureja parvifolia and
Senecio eriophyton were tested for their relaxant activity on smooth
muscle using L-phenylephrine precontracted strips of corpus cavernosum
obtained from Guinea pigs. Highly significant and dose dependent results
were obtained with the dichloromethane extracts of H. saururus (87% of
relaxation at the dose of 10 mg/ml), S. parvifolia (95% of relaxation at
2.5 mg/ml) and S. eriophyton (94% of relaxation at 5 mg/ml). Similar
effects were observed with the methanol extracts of H. saururus (88% of
relaxation at 10 mg/ml) and S. parvifolia (84% of relaxation at 10
mg/ml). These results were comparable to those obtained with the
dichloromethane and methanol extracts of the well known Mexican species
Turnera diffusa. Moreover, the aqueous extract of H. rigidus and the
aqueous and methanol extracts of S. eriophyton were highly effective in a
dose dependent manner (more than 90% of relaxation at the dose of 10
mg/ml). Significant results, but with a lower overall relaxant activity
(about 70% of relaxation at 10 mg/ml), could also be obtained with the
aqueous extract of S. parvifolia and with the dichlormethane and
methanol extracts of B. trimera and M. ilicifolia. The positive controls
with Sildenafil citrate at doses ranging from 0.35 to 35 microg/ml
yielded moderate effects (up to 46% of relaxation at 35 microg/ml). The
effects observed in the present study seem to validate the folk
medicinal use of the tested plants and open new ways in the search for
natural products with vasodilatory effects.
PMID: 14692728 [PubMed - indexed for MEDLINE]
Milky Oats Avena sativa
10. Diets containing soluble oat extracts improve
glucose and insulin responses of moderately hypercholesterolemic men and
women.
Hallfrisch J, Scholfield DJ, Behall KM.
US Department of Agriculture, Beltsville Human Nutrition Research
Center, MD 20705.
Am J Clin Nutr. 1995 Feb;61(2):379-84.
The high amount of soluble beta-glucans in oats may be responsible for
beneficial effects on glucose tolerance and blood lipids. We studied 16
women and 7 men (aged 38-61y) with moderately high cholesterol
concentrations who consumed normal diets to which oat extracts with
either 1% or 10% soluble beta-glucans were added. Oat extracts comprised
10% of energy and were consumed in a 5-wk crossover design after a 1-wk
equilibration period. At the end of the equilibration period and each
5-wk period, a carbohydrate tolerance test was conducted and responses
to glucose, glucose plus oat extract containing 1% glucan, or glucose
plus oat extract containing 10% glucan were determined. Glucose
responses were reduced by both extracts in both men and women; however,
in women, responses to the 10% extract were lowest. Insulin responses
did not differ between men and women, but were lower after oat extracts.
Glucagon responses were higher initially in men and were lowered after
oat extracts in men but not in women. Modest amounts of oat extracts can
be incorporated into normal diets with beneficial effects on glucose
tolerance factors.
Publication Types: Clinical Trial, Controlled Clinical Trial
PMID: 7840078 [PubMed - indexed for MEDLINE]
Rosemary Rosmarinus officinalis
11. Antiplatelet activity of carnosic acid, a
phenolic diterpene from Rosmarinus officinalis.
Lee JJ, Jin YR, Lee JH, Yu JY, Han XH, Oh KW, Hong JT, Kim TJ, Yun YP.
College of Pharmacy, Research Center for Bioresource and Health,
Chungbuk National University, Cheongju, Korea. Planta Med. 2007
Feb;73(2):121-7.
Carnosic acid is a major phenolic diterpene derived from Rosmarinus
officinalis and has been reported to have antioxidant, antibacterial,
anticancer, antiobese and photoprotective activities. This study
investigated the antiplatelet activity of carnosic acid. carnosic acid
significantly inhibited collagen-, arachidonic acid-, U46619- and
thrombin-induced washed rabbit platelet aggregation in a
concentration-dependent manner, with IC50 values of 39+/-0.3, 34+/-1.8,
29+/-0.8 and 48+/-2.9 microM, respectively, while it failed to inhibit
PMA-(a direct PKC activator) and ADP-induced platelet aggregation. In
agreement with its antiplatelet activity, carnosic acid blocked
collagen-, arachidonic acid-, U46619- and thrombin-mediated cytosolic
calcium mobilization. accordingly, serotonin secretion and arachidonic
acid liberation were also inhibited in a similar concentration-dependent
manner. However, in contrast to the inhibition of arachidonic
acid-induced platelet aggregation, carnosic acid had no effect on the
formation of arachidonic acid-mediated thromboxane A2 and prostaglandin
D2, thus indicating that carnosic acid has no effect on the
cyclooxygenase and thromboxane A2 synthase activity. Overall, these
results suggest that the antiplatelet activity of carnosic acid is
mediated by the inhibition of cytosolic calcium mobilization and that
carnosic acid has the potential of being developed as a novel
antiplatelet agent.
PMID: 17410649 [PubMed - in process]
Raspberry Leaf Rubus ideaus
12. Therapeutic constituents and actions of Rubus
species.
Patel AV, Rojas-Vera J, Dacke CG.
School of Pharmacy and Biomedical Sciences, University of Portsmouth,
Portsmouth, PO1 2DT, UK. asmita.sautreau@port.ac.uk
Curr Med Chem. 2004 Jun;11(11):1501-12.
Rubus species (family Rosaceae) have been cultivated for centuries for
their fruits. These and other parts of the plants have been used
traditionally for therapeutic purposes. This article highlights these
and the potential they can offer. The constituents reported in the
various species and those demonstrated to exhibit pharmacological
properties have been reviewed. In the search for biologically active
compounds, one of the most frequently documented species of the genus is
the raspberry plant R. idaeus, the leaves of which have been used
traditionally as a uterine relaxant and stimulant during confinement,
for the treatment of diarrhoea and similar enteric disorders and as an
astringent. Investigations of other Rubus species have been conducted in
the last twenty-five years, and have shown possible application for a
wide range of indications, including bacterial infections, anxiety, pain
and inflammation.
Publication Types: Review, Review, Tutorial
PMID: 15180580 [PubMed - indexed for MEDLINE]
13. Relaxant activity of raspberry (Rubus idaeus)
leaf extract in guinea-pig ileum in vitro.
Rojas-Vera J, Patel AV, Dacke CG.
School of Pharmacy and Biomedical Sciences, University of Portsmouth,
Portsmouth, PO1 2DT, UK.
Phytother Res. 2002 Nov;16(7):665-8.
Tea made from the leaves of Rubus idaeus L. (raspberry) has been used
for centuries as a folk medicine to treat wounds, diarrhoea, colic pain
and as a uterine relaxant. Extracts of dried raspberry leaves prepared
with different solvents, (n-hexane, ethyl acetate, chloroform and
methanol) were tested in vitro for relaxant activity on transmurally
stimulated guinea-pig ileum. The methanol (MeOH) extract exhibited the
largest response and also indicated that the active compounds are of a
relatively polar nature. Hence the bulk of the leaves were extracted
with methanol and the dried extract fractionated on a silica gel column,
eluting with chloroform, mixtures of chloroform and methanol and
finally methanol. Each fraction was examined by thin layer
chromatography and tested for relaxant activity in an in vitro
transmurally stimulated guinea-pig ileum preparation. The fractions
eluted with chloroform (CHCl(3)) lacked relaxant activity. Samples
eluted with CHCl(3)/MeOH (95:5) had moderate relaxant activity, while a
second distinctive peak of activity eluted with a more polar solvent
mixture (CHCl(3)/MeOH 50:50) provided strong dose dependent responses.
Evidence was obtained that there are at least two components of
raspberry leaf extract which exhibit relaxant activity in an in vitro
gastrointestinal preparation. Copyright 2002 John Wiley & Sons, Ltd.
PMID: 12410549 [PubMed - indexed for MEDLINE]
Disclaimer: Statements on this page
have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure or prevent any disease.
Information on this publication should not be used as medical advice.
Data prvided for research and professional use only
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